Table 2.
Effect of different drug treatments on liver antioxidant enzymes and lipid peroxidation levels in CCl4-intoxicated rats
| Group | Treatment | SOD (U/mL) | CAT (nmol/min/mL) | TBARS (nmol/g tissue) |
|---|---|---|---|---|
| I | DW + olive oil (1 mL/kg) | 10.6±1.2 | 6.1±0.7 | 145.3±6.9 |
| II | CCl4 (1 mL/kg) | 1.8±0.3$ | 1.1±0.1$ | 364.85±9.6$ |
| III | Silymarin (100 mg/kg) + CCl4 (1 mL/kg) | 7.5±0.7* | 4.4±0.6* | 178.3±7.6* |
| IV | SGNPs (10 mg/kg) + CCl4 (1 mL/kg) | 6.7±0.6* | 3.9±0.5* | 182.8±8.3* |
| V | SGNPs (20 mg/kg) + CCl4 (1 mL/kg) | 8.5±0.8* | 5.3±0.6* | 159.1±7.4*,^ |
| VI | GSGNPs (10 mg/kg) + CCl4 (1 mL/kg) | 8.3±0.7* | 4.9±0.4* | 163.8±8.1* |
| VII | GSGNPs (20 mg/kg) + CCl4 (1 mL/kg) | 9.6±0.8*,^ | 5.8±0.6*,^ | 152.5±7.7*,^ |
Notes: All the results are expressed as mean ± SD (n=6).
$
P<0.05, comparison of Group II with Group I.
*
P<0.05, comparison of Groups III–VII with Group II.
^
P<0.05, comparison of Groups IV–VII with Group III.
Abbreviations: SOD, superoxide dismutase; CAT, catalase; TBARS, thiobarbituric acid-reacting substance; DW, distilled water; SGNPs, silymarin-tethered gold nanoparticles; GSGNPs, SGNPs aggregated in glycogen.