Skip to main content
. 2017 Oct 3;6:e29738. doi: 10.7554/eLife.29738

Figure 1. MRI-visualization of dural lymphatic vessels in human and nonhuman primates.

In both species, conventional post-gadobutrol coronal T1-weighted MRI is unable to discriminate lymphatic vessels due to diffuse physiological enhancement of the dura (arrows) and blood vessels, including the superior sagittal sinus and straight sinus (arrows). On post-gadobutrol coronal T2-FLAIR and subtraction images, the dura does not enhance, and lymphatic vessels (red arrows), running alongside the venous dural sinuses and within the falx cerebri, can be appreciated. Numbers refer to minutes after the intravenous administration of gadobutrol.

Figure 1.

Figure 1—figure supplement 1. 3D rendering of human dural lymphatics.

Figure 1—figure supplement 1.

3D rendering of putative dural lymphatics (black) in a 47 year old woman, derived from skull-stripped subtraction T1-black-blood images (same case as in Video 1). Thumbnails are 3D renderings of the brain parenchyma to aid visualization of image orientation.