Table 1. Summary of effects of small molecule signaling inhibitors on IGF-I and IGF-II induction of pax3 and MyoD expression in developing limb of chick embryos.
| Graft at HH 17, incubate for 24h | pax3 induction | Graft at HH 19, incubate for 18h | MyoD induction | ||
| IGF-I | 28/34 | 82% | IGF-I | 19/25 | 76% |
| IGF-I + PPP | 6/18 | 33% | IGF-I + PPP | 2/9 | 22% |
| IGF-I + U0126 | 1/10 | 10% | IGF-I + U0126 | 1/8 | 12.5% |
| IGF-I + LY294002 | 5/6 | 83% | IGF-I + LY294002 | 4/19 | 21% |
| IGF-I + SU5402 | 17/25 | 68% | IGF-I + SU5402 | 10/30 | 33% |
| IGF-I + DMSO | 8/10 | 80% | IGF-I + DMSO | 11/16 | 69% |
| Graft at HH 17, incubate for 24h | pax3 induction | Graft at HH 19, incubate for 18h | MyoD induction | ||
| IGF-II | 22/30 | 73% | IGF-II | 24/35 | 69% |
| IGF-II + PPP | 3/11 | 27% | IGF-II + PPP | 3/11 | 27% |
| IGF-II + U0126 | 1/7 | 14% | IGF-II + U0126 | 4/12 | 33% |
| IGF-II + LY294002 | 7/21 | 33% | IGF-II + LY294002 | 9/14 | 64% |
| IGF-II + SU5402 | 6/8 | 75% | IGF-II + SU5402 | 4/16 | 25% |
| IGF-II + DMSO | 6/6 | 100& | IGF-II + DMSO | 12/19 | 63% |