Fig 4. Dot plot of human Chr15:27,500,001–29,000,000 against dog Chr3:31,500,001–33,000,000.

The human OCA2 gene spans 380 kb. The dot plot illustrates that ~300 kb of dog reference sequence are inverted with respect to the human sequence due to an assembly error in the current CanFam 3.1 assembly. Due to this assembly error the first two exons of the canine OCA2 gene are currently in the wrong orientation and annotated as LOC100855460.