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. 2017 Oct 2;216(10):3117–3132. doi: 10.1083/jcb.201610012

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© 2017 Tipton et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).

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Figure 8. — GTSE1 undergoes dynamic relocalization during mitosis. Before NEB, GTSE1 plus end tip tracks on microtubules (MTs) in an EB1-dependent fashion. After NEB, GTSE1 microtubule plus end tip tracking is suppressed, allowing the relocalization of GTSE1 to the lattice of slow-turnover microtubules in the mitotic spindle. GTSE1 relocalization allows it to promote turnover of the slow-turnover microtubule population. Upon anaphase onset, GTSE1 microtubule plus end tip tracking is reinstated, allowing GTSE1 to primarily decorate the fast-turnover astral microtubule population.