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. 2017 Oct 2;216(10):3339–3354. doi: 10.1083/jcb.201612169

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© 2017 McLennan et al.

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Figure 9. — Schematic representations of expression and perturbations of DAN. (A) Expression of DAN in the mesoderm and migrating neural crest cells at HH St 11, 13, and 15. Neural crest cells initially are migrating within the DAN-rich corridor (HH St 11), but then lead neural crest cells migrate through the DAN-rich corridor (HH St 13) and go on to invade the branchial arch target tissue (HH St 15). The width of the DAN-rich corridor increases over time, which is consistent with domain growth. (B) When DAN expression is knocked down, more neural crest cells are present in the stream. (C) When DAN is overexpressed, less neural crest cells are present in the stream.