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. 2017 Oct 2;216(10):3051–3060. doi: 10.1083/jcb.201703201

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© 2017 Huynh and Vale

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Figure 5. — Overexpression of BICD2 mutants in rat hippocampal neurons results in a decrease in neurite length. (A) Representative images of hippocampal neurons overexpressing mCherry–BICD2_FL (WT and mutants) or an empty plasmid control; neurons were also cotransfected with soluble GFP in order to mark the neurites. Bar, 10 µm. (B) Axon length after 3 d of overexpression of BICD2_FL constructs; mean and SD from n = 3 independent experiments (each experiment measuring 15–20 neurons for each construct); *, P ≤ 0.05. (C) Total neurite length after 3 d of overexpression of BICD2_FL constructs; mean and SD from n = 3 independent experiment (each experiment measuring 15–20 neurons for each construct); **, P ≤ 0.01. (D) Model of how a gain of function in dynein-based motility from BICD2 mutants might cause an imbalance in axonal transport and lead to SMA. See Discussion for more details.