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. 2017 Oct 2;216(10):3249–3262. doi: 10.1083/jcb.201704015

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© 2017 Selyunin et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).

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Figure 1. — Classification and analyses of hits obtained in the primary and secondary siRNA screens. (A) Schematic illustrating annotated functions of hits identified in the primary genome-wide siRNA screen. Functions were retrieved from the universal protein resource database (UniProt). Note that one gene can have multiple annotated functions; therefore, numbers here do not match those provided in the supplemental tables. (B) Graph depicting hits that were unique to STx2 in the primary screen and predicted to localize to endosomes/Golgi. (C) Secondary screen data. Each gene was targeted with four separate siRNAs.