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. 2017 Oct 2;216(10):2999–3001. doi: 10.1083/jcb.201708069

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© 2017 Gekara

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Figure 1. — Micronuclei serve as a source of immunostimulatory DNA. Cell division after DNA damage leads to micronuclei formation. cGAS sensing of micronuclei DNA triggers gene activation, which may lead to autoinflammation or antitumor immunity. Micronuclei can be cleared via autophagy.