Skip to main content
. Author manuscript; available in PMC: 2018 Oct 15.
Published in final edited form as: Cancer. 2017 Jun 22;123(20):4066–4074. doi: 10.1002/cncr.30829

Table 2. Top 10 metabolites differentially expressed between CRC, PLP and CTRL groups in the discovery set.

Metabolite CRC PLP CTRL P value




N Mean (SD) N Mean (SD) N Mean (SD) CTRL vs PLP CTRL vs CRC PLP vs CRC P for trend
Hypoxanthine 30 13.29( 0.49) 30 13.63( 0.67) 30 15.53( 1.33) <0.01 <0.01 0.06 <0.01
D-Mannose 30 22.44( 0.57) 30 22.16( 0.75) 30 21.62( 0.83) <0.01 <0.01 0.21 <0.01
DSGEGDFXAEGGGVR* 30 18.87( 1.90) 30 17.50( 1.64) 30 16.81( 2.11) 0.09 <0.01 <0.01 <0.01
Xanthine 30 15.79( 0.51) 30 16.12( 0.42) 30 16.41( 0.70) 0.11 <0.01 0.01 <0.01
Glutamate 30 22.14( 0.70) 30 22.44( 0.81) 30 22.73( 0.76) 0.1 <0.01 0.07 <0.01
Tryptophylglutamate 30 12.99( 1.11) 30 13.28( 0.77) 30 13.83( 1.16) 0.07 <0.01 0.08 <0.01
3-methyl-2-oxobutyrate 30 14.65( 0.38) 30 14.89( 0.33) 30 14.26( 0.40) <0.01 <0.01 <0.01 <0.01
5-oxoproline 30 15.89( 0.36) 30 16.12( 0.59) 30 16.31( 0.63) 0.12 <0.01 0.08 <0.01
Lactate 30 28.58( 0.64) 30 28.83( 0.50) 30 29.02( 0.71) 0.09 <0.01 0.09 <0.01
1,3-dipalmitoylglycerol 30 15.09( 0.88) 30 15.63( 0.75) 30 15.75( 0.92) 0.51 <0.01 0.03 <0.01

Mean level in ng/μL or μg/mL; CRC, colorectal cancer; PLP, adenoma polyp; CTRL, control; SD, standard deviation

Boldface metabolites were selected for further validation.

*

Small peptide not officially multiplexed by Metabolon based on a standard