Table 2.

Association of treatment and other variables with cisplatin-induced peripheral neuropathy. Bolded variables are significantly associated at α = 0.05.

A. Treatment Variables
Model	Variable	OR (95% CI)	P-value
CisIPN ~ Variable	Age at diagnosis	1.06 (1.05–1.07)	2 × 10−9
CisIPN ~ Variable (+Agediagnosis)	BMI at treatment	1.00 (0.97–1.03)	0.96
	Cisplatin dosea (mg/m2)	1.00 (0.99–1.00)	0.39
B. Variables at Clinical Evaluation
CisIPN ~ Variable	Age at evaluation	1.04 (1.03–1.06)	2 × 10−8
CisIPN ~ Variable (+Agediagnosis)	Smokingb	1.54 (1.15–2.07)	0.004
	Excess drinkingc	1.83 (1.18–2.84)	0.007
	Hypertensiond	1.61 (1.04–2.50)	0.03
	BMI at evaluation	1.03 (1.00–1.05)	0.051
	Diabetese	1.27 (0.54–2.95)	0.59
	Hypercholesterolemiaf	0.92 (0.57–1.48)	0.72
C. Multivariate model
CisIPN ~ Significant Variables	Agediagnosis	1.04 (1.02–1.06)	3 × 10−6
	Excess drinking	1.82 (1.16–2.86)	0.009
	Smoking	1.56 (1.15–2.10)	0.004
	Hypertension	1.54 (0.97–2.42)	0.065

^aDose group was an ordinal variable created from cumulative cisplatin doses (in mg/m²) classified as follows: <300, 300–400 (excluding 400), 400–500 (excluding 500), and ≥500. OR is based on ordinal group.

^bIncludes patients who answered yes to the question “have you ever smoked cigarettes?”

^cIncludes patients who answered answered ≥ 2 drinks/day to the question “during the past year, how many drinks of alcoholic beverage have you consumed?”

^dIncludes patients who answered yes to both of the following: 1) “have you ever been diagnosed with high blood pressure?” and 2) “are you currently taking prescription medication for high blood pressure?”

^eIncludes those patients who answered “yes” to either of the following questions: 1) “diabetes requiring insulin?” or 2) “diabetes requiring tablets or pills?”.

^fIncludes those patients who are currently taking prescription medications for high cholesterol.