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. Author manuscript; available in PMC: 2018 Oct 1.
Published in final edited form as: Cancer Res. 2017 Jul 31;77(19):5349–5359. doi: 10.1158/0008-5472.CAN-17-0061

Figure 1. Characterization of gastric adenocarcinoma in triple conditional mice (Atp4b-Cre;Cdh1fl/fl,Trp53fl/fl;KrasLSLG12D/+ or Tcon).

Figure 1

(A) Survival curve demonstrating 76.5 day median survival (n=20) of Tcon mice (red) compared to 322 day median survival (n=19) of double conditional mice (Atp4b-Cre;Cdh1fl/fl,Trp53fl/fl or KrasWT mice; blue). (B) Graph representing the weights of individual Tcon and Dcon mice in survival analysis over time. (C) Representative gross image of a wild-type stomach and a Tcon stomach (67 and 77 days of age, respectively, scale bar: 1 cm). (D) Representative images of intestinal-type and diffuse-type lesions found in Tcon mice. (E) Representative H&E and immunofluorescence (blue: DAPI, yellow: YFP) images of Tcon and Cre- control stomachs harvested from mice at 3, 6, and 9 weeks of age (scale bar: 1 mm).