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. Author manuscript; available in PMC: 2018 Oct 1.
Published in final edited form as: Cancer Res. 2017 Aug 14;77(19):5313–5326. doi: 10.1158/0008-5472.CAN-17-0986

Figure 2. Loss of HNF1B correlates with aneuploidy in ChRCC patients and not with chromosome 17 loss.

Figure 2

Copy number (CN) alteration of frequently lost chromosomes (1, 2, 6, 10, 13, 17) in HNF1B high (N=8) and HNF1B low (N=58) groups. Hierarchical clustering constructed with Euclidean distance and Ward’s linkage. One row represents one frequently lost chromosome arm, and one column represents one patient (A). Whole chromosome CN loss frequencies in HNF1B high and HNF1B low groups (B). HNF1B mRNA level comparisons among stage I–IV patients by ANOVA (C). Total number of chromosome CN change in stage I–IV patients by ANOVA (D). Correlation between patient stage and chromosome 17 CN loss via Fisher exact test (E). HNF1B mRNA levels in normal controls (N=25), tumor CN neutral (N=16) and tumor CN abnormal (N=50) groups by ANOVA (F).