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. Author manuscript; available in PMC: 2018 Oct 1.
Published in final edited form as: Cancer Res. 2017 Aug 14;77(19):5339–5348. doi: 10.1158/0008-5472.CAN-16-3410

Figure 2.

Figure 2

SIN3B prevents Pten deletion-induced prostate cancer. A, Representative images of prostates taken from twelve-month-old Sin3bpc+/−, Sin3bpc−/−, Sin3bpc+/− Ptenpc−/−, and Sin3bpc−/− Ptenpc−/− mice. n = 4, 5, 8, 7 respectively. B, Weight in grams of whole prostates taken from three, six and twelve month-old Sin3bpc+/− (n = 5, 4, 5), Sin3bpc−/− (n = 4, 4, 5), Sin3bpc+/− Ptenpc−/− (n = 10, 6, 8), and Sin3bpc−/− Ptenpc−/− (n = 9, 10, 7) mice, respectively. * p<0.05 via student’s t-test. C–E, Representative images of H&E staining on paraffin sections of the dorsolateral lobe of prostates taken from three-, six-, and twelve-month-old Sin3bpc+/− (n = 5, 4, 5), Sin3bpc−/− (n = 4, 4, 5), Sin3bpc+/− Ptenpc−/− (n = 10, 6, 8), and Sin3bpc−/− Ptenpc−/− (n = 9, 10, 7) mice, respectively. Top Panel = 10× magnification. Bottom Panel = 40× magnification. Scale bar = 200 μm.