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Loss of Sin3b-induced PCa is lethal and occurs late in life. A, Kaplan-Meier survival curve of Sin3bpc+/− Ptenpc−/− (black, n = 19) and Sin3bpc−/− Ptenpc−/− (red, n = 15) mice. ** p=0.0065. B, Quantification of pathological scoring conducted using H&E stained sections taken from three, six, and twelve-month-old Sin3bpc+/− (n = 5, 4, 4), Sin3bpc−/− (n = 4, 4, 5), Sin3bpc+/− Ptenpc−/− (n = 10, 6, 8), and Sin3bpc−/− Ptenpc−/− (n = 9, 10, 7) mice, respectively.
