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Two-dimensional SDS-PAGE is utilized to study the impact of ethanol metabolism on the isoelectric point of SOD2. Liver mitochondrial extracts from both control and ethanol-fed mice were separated using 2D electrophoresis and probed with (A) anti-SOD2 and (B) anti-SOD2 ac-K68 antibodies results here reveal that chronic ethanol consumption induces a major shift in the isoelectric point of SOD2 in murine hepatic mitochondria due in large part to protein acetylation and other PTMs.
