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. Author manuscript; available in PMC: 2017 Oct 4.
Published in final edited form as: Nat Rev Urol. 2017 Jul 4;14(10):607–619. doi: 10.1038/nrurol.2017.104

Figure 3. Potential applications directed at telomeres and telomerase in prostate cancer management.

Figure 3

At the diagnostic stage, detection of telomerase expression and measurement of telomere length might be useful, as telomerase activation and shortened telomeres are strongly associated with prostate cancer. At the prognostic level, determining telomere lengths might enable distinguishing men who will develop lethal metastatic disease from men whose disease is unlikely to advance beyond an organ-confined stage. At the therapeutic level, strategies targeting telomerase or telomeres might have clinical utility, particularly in combination with traditional prostate cancer therapies that target the androgen signalling pathway.