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. Author manuscript; available in PMC: 2017 Oct 4.
Published in final edited form as: Clin Trials. 2008;5(2):93–106. doi: 10.1177/1740774508089279

Figure 1.

Figure 1

Operating characteristics for 1,000 simulated trials under three scenarios for Example 1: 3 stages, 10 stages, and a random number of stages, all with random cohort sizes. Subpanels: (A) Type I error rates, (B) Power for detecting a response rate of 40%, (C) Probability of early termination if the true response rate is 20% and (D) Expected sample size if the true response rate is 20%. Line types: ……Simon’s minimax two-stage design, -----Predictive probability design, monitoring every patient, -·-·- Predictive probability design, monitoring every 5 patients.