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. Author manuscript; available in PMC: 2017 Oct 4.
Published in final edited form as: Clin Trials. 2008;5(2):93–106. doi: 10.1177/1740774508089279

Table 2.

Operating characteristics of Simon’s two-stage designs and the PP design with type I and type II error rates ≤ 0.10, prior for p = beta(0.2,0.8), p0=0.2, p1=0.4

Simon’s Minimax/Optimal 2-Satge
r1/n1 r/Nmax PET(p0) E(N| p0) α β
Minimax 3/19 10/36 0.46 28.26 0.086 0.098
Optimal 3/17 10/37 0.55 26.02 0.095 0.097
Predictive Probability
θL θT r/Nmax PET(p0) E(N| p0) α β
0.001 [0.852,0.922]* 10/36 0.86 27.67 0.088 0.094
0.011 [0.830,0.908] 10/37 0.85 25.13 0.099 0.084
0.001 [0.876,0.935] 11/39 0.88 29.24 0.073 0.092
0.001 [0.857,0.923] 11/40 0.86 30.23 0.086 0.075
0.003 [0.837,0.910] 11/41 0.85 30.27 0.100 0.062
0.043 [0.816,0.895] 11/42 0.86 23.56 0.099 0.083
0.001 [0.880,0.935] 12/43 0.88 32.13 0.072 0.074
0.001 [0.862,0.924] 12/44 0.87 33.71 0.085 0.059
0.001 [0.844,0.912] 12/45 0.85 34.69 0.098 0.048
0.032 [0.824,0.898] 12/46 0.86 26.22 0.098 0.068
0.001 [0.884,0.936] 13/47 0.89 35.25 0.071 0.058
0.001 [0.868,0.925] 13/48 0.87 36.43 0.083 0.047
0.001 [0.850,0.914] 13/49 0.86 37.86 0.095 0.038
0.020 [0.832,0.901] 13/50 0.86 30.60 0.100 0.046
*

The numbers within the bracket indicate a closed interval with both endpoints included.