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. Author manuscript; available in PMC: 2017 Oct 4.
Published in final edited form as: Clin Trials. 2008;5(2):93–106. doi: 10.1177/1740774508089279

Table 3.

Operating characteristics of Simon’s two-stage designs and the PP design with type I error rate ≤ 0.05 and type II error rate≤0.20, prior for p = beta(0.6,0.4), p0=0.6, p1=0.8

Simon’s Minimax/Optimal 2-Satge
r1/n1 r/Nmax PET(p0) E(N| p0) α β
Minimax 8/13 25/35 0.65 20.77 0.050 0.192
Optimal 7/11 30/43 0.70 20.48 0.049 0.198
Predictive Probability
θL θT r/Nmax PET(p0) E(N| p0) α β
[0.075,0.079] [0.924,0.963]* 25/35 0.94 16.87 0.050 0.1855
0.001 [0.940,0.972] 26/36 0.94 23.16 0.045 0.168
0.001 [0.953,0.978] 27/37 0.96 23.05 0.035 0.191
[0.061,0.067] [0.925,0.963] 27/38 0.94 18.20 0.050 0.158
0.001 [0.941,0.971] 28/39 0.94 25.12 0.045 0.141
0.001 [0.953,0.978] 29/40 0.96 24.87 0.035 0.161
0.051 [0.927,0.962] 29/41 0.94 19.57 0.0500 0.135
0.001 [0.942,0.971] 30/42 0.94 27.28 0.045 0.119
0.001 [0.954,0.977] 31/43 0.96 26.88 0.035 0.136
0.051 [0.929,0.962] 31/44 0.94 21.40 0.050 0.111
*

The numbers within the bracket indicate a closed interval with both endpoints included.