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. 2017 Oct 3;7:12580. doi: 10.1038/s41598-017-12996-y

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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ATR-AP205-001 efficiently reduced blood pressure and target organ damages of Ang II induced hypertensive mice. (A) Anti-ATR001 antibody titers were measured by ELISA on days 14, 21, 28 and 35 after ATR-AP205-001 and ATR-Dimer-001 vaccination. n = 8 per group. *P < 0.05, ***P < 0.001 vs. ATR-Dimer-001. (B) Blood pressure of mice was tested by tail-cuff method on days 0, 20, 25, 30 and 35. **P < 0.01 vs. NS + Ang II group. (C) Masson trichrome staining identified fibrosis (marked by black arrows) of heart tissue in each group. Cardiomyocyte diameter was identified by the length perpendicular to the long axis of the cell (n = 20 myocytes per group). Scale bars, 50 μm (upper) and 10 μm (lower). (D) The ratio of fibrotic area to total heart tissue and (E) myocytes diameter tested in ImageJ. *P < 0.05 vs. NS + Ang II group, ^#P < 0.01 vs. ATR-Dimer-001 group. A-A: ATR-AP205-001, A-D: ATR-Dimer-001, Val: valsartan, and NS: natural saline in this Figure. Data are expressed as mean ± SEM.