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. 2017 Oct 3;7:12580. doi: 10.1038/s41598-017-12996-y

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Follicle B cells participated in ATR-AP205-001 transportation. (A) Co-localization of ATR -AP205-001 and ATR-Dimer-001 with DCs (CD11c⁺, red), SCS Mφs (CD169⁺, red) and follicle B cells (IgD⁺, blue) in dLNs. (B) Higher magnification co-localization images of ATR-AP205-001 and ATR-Dimer-001 with SCS Mφs and follicle B cells after 2 hours vaccination. Red arrows annotate vaccines co-localization with SCS Mφs, white arrows annotate vaccines carried by B cells. (C) Proportions of DCs (CD11c⁺), SCS Mφs (CD14⁺CD169⁺), and B cells (CD19⁺) gated on ATR001⁺ population after ATR-AP205-001 immunization. (D) Co-localization of ATR-AP205-001 with follicle B cells and FDCs in untreated and CLL-pretreated dLNs. n = 6 per group. Data are expressed as mean ± SEM. Scale bars, 100 μm.