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. 2017 Oct 3;7:12622. doi: 10.1038/s41598-017-13025-8

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Serum and tissue erlotinib concentrations in the mouse xenograft model (A) Serum erlotinib concentration by liquid chromatography-tandem mass spectrometry (B) Erlotinib concentrations in the tissue sections was compared between tumor and normal lung tissues. Blue bar indicates erlotinib concentration by liquid chromatography-tandem mass spectrometry. Purple bar indicates erlotinib ion intensity per section by matrix-assisted laser desorption ionization mass spectrometry imaging. Error bar = standard deviation of replicate samples.