Fig. 1.

a. ACQ score in a 12-month study period divided per cluster. Time period 0 is the baseline measurement. A high ACQ scores stands for less controlled asthma. ACQ-scores can be divided in: controlled (ACQ score ≤ 0.75, below green dotted line), partly controlled (0.75 < ACQ score < 1.5), or uncontrolled (ACQ score ≥ 1.5, above red dotted line). The clusters started out with different baseline scores. The ‘exacerbators’ and ‘reversible’ phenotypes started as uncontrolled, but after 12 months progressed to partly controlled. The ‘smokers’ and ‘late onset female’ managed as partly controlled.³³ The only group with controlled asthma is the early atopic group. b. AQLQ scores in a 12-month study period divided per cluster. Time period 0 is the baseline measurement. Higher AQLQ scores mean a better quality of life. The ‘late onset female’ and the ‘smokers’ have comparable starting and ending values, and a small progress can be noted for both groups. The reversible and exacerbation phenotypes have the highest increase in quality of life in the 12-month study period, albeit still lower than the other phenotypes. In all groups a decrease in scores can be noted if month 12 is compared to month 9