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. 2017 Oct 3;7:12589. doi: 10.1038/s41598-017-12955-7

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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A bioinformatics analysis of the human MAPT gene’s alternative promoter. (A) The various transcripts of the MAPT gene reported in Ensembl: the six conventional transcripts of MAPT and five shorter transcripts starting in exon 1. (B) The exon 1 of MAPT and its upstream region are conserved in mammals, as shown by alignment with the human Hg19 DNA sequences of MAPT orthologues in various organisms, using the ECR browser (https://www.ecrbrowser.dcode.org). Exon 1’s coding sequences are shown in blue and the non-coding sequences are shown in yellow. (C) Sequence of the putative alternative promoter of MAPT. Exon 1’s sequence is depicted in red capital letters. Putative transcription factor binding sites (obtained with RSAT software and the TRANSFAC database) are marked with a white box, a gray box and in blue. The GC box is underlined in pink. Two ATG codons (corresponding to methionines 1 and 11) are framed in red.