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. 2017 Oct 3;7:12628. doi: 10.1038/s41598-017-13051-6

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Surrogate markers of oxidative stress are inversely associated with LpPLA₂ in placenta and foetal circulation. (a and b) Western Blot of control and GDM placental tissue lysates against LpPLA₂ (a) and oxidized phospholipid residues (E06 oxPL) (b). ß-Actin was used for normalization as loading control. One representative out of N ≥ 3 experiments is shown. Images shown have been cropped; uncropped original files are available as Supplementary Information. (c and d) Densitometric analysis of LpPLA₂ protein and proteins modified by oxidized phospholipids (oxPL) in control and GDM placentae (N = 12 per group). Data from 3 individual experiments were pooled, mean ± SD, t-test. (e) Thiobarbituric acid reactive species (TBARS) were measured as surrogate of oxidative stress in neonatal cord plasma (mean ± SD, N = 16 per group, t-test). (f) Pearson correlation of TBARS levels in foetal circulation with HDL-LpPLA₂.