Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Oct 3;7:12612. doi: 10.1038/s41598-017-11674-3

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Lack of endometrial SGLT1 is associated with smaller liter size and lower birth weight in mice and recurrent pregnancy loss in humans. WT male and female mice were crossed with Slc5a1 ^−/− females (n = 5), and males, respectively (n = 6). Arithmetic means ± SEM are shown. (a) Number of implantation sites at 7.5 d.p.c. (b) Pups per litter, and (c) Birth-weight of corresponding heterozygotic pups. (d) Comparison of endometrial SLC5A1 transcripts in patients without a history of pregnancy loss (Con; n = 9) or patients with recurrent pregnancy loss (RPL; n = 9). Transcript levels are expressed as transcripts per million (TPM). The data were derived from in silico analysis of publicly available microarray data [Gene Expression Omnibus (GEO) Profiles; ID: GSE65102]. (e) SGLT1 protein levels in mid-luteal endometrial biopsies from Control subjects (n = 5) and RPL patients (n = 5) was assessed by Western blot analysis and normalized to GAPDH expression. The original Western blot data are shown in Figure S6. The densitometry data represent arithmetic means ± SEM. **Indicates P < 0.01 (Student’s t-test).