Table 2.

Characterization of the upregulation in splice correction activity induced by small molecule ligands.

Splice correction activation ligands	EC50 (nM) ± SEM
Pifithrin-μ (selective inhibitor of heat shock protein 70 (HSP70))	0.92 ± 0.51
Alprenolol hydrochloride (β-adrenoceptor antagonist)	47000 ± 120
CH-223191 (aryl hydrocarbon receptor (AhR) antagonist)	676 ± 0.26
Importazole (nuclear transport receptor importin-β inhibitor)	650 ± 460
TLR-4-IN-C34 (TLR4 inhibitor)	76 ± 0.32
MHY1485 (mTOR activator)	9.39 ± 0.61

Pifithrin-μ “2-Phenylethynesulfonamide”, Alprenolol hydrochloride “1-(o-Allylphenoxy)-3-(isopropylamino)-2-propanol hydrochloride“, CH-223191 “1-Methyl-N-[2-methyl-4-[2-(2-methylphenyl)diazenyl]phenyl-1H-pyrazole-5-carboxamide”, Importazole “N-(1-Phenylethyl)-2-(pyrrolidin-1-yl)quinazolin-4-amine”, TLR-4-IN-C34 “2-Acetamidopyranoside, C34, Isopropyl 2-(acetylamino)-2-deoxy α-D-glucopyranoside 3,4,6-triacetate” and MHY1485 “4,6-Di-4-morpholinyl-N-(4-nitrophenyl)-1,3,5-triazin-2-amine”.