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. 2017 Oct 3;7:12593. doi: 10.1038/s41598-017-12827-0

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Folding kinetics of PDZ3 and PDZ3Δα3 at neutral pH. Panel A. Representative folding (black) and unfolding (grey) kinetic traces recorded for PDZ3Δα3, the lines are the best fit to a single exponential decay. Panel B. The logarithmic values of the folding and unfolding rate constant of PDZ3 (empty circles) and PDZ3Δα3 (filled circles) were plotted and fitted to a two-state folding equation. The experiments suggest that truncation of α3 decreases the stability of the native state by increasing the unfolding rate constant.