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. 2017 Oct 3;7:12593. doi: 10.1038/s41598-017-12827-0

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Folding kinetics of PDZ3 (left) and PDZ3Δα3 (right) at different experimental conditions. Panel A and B: Chevron plots of the logarithm of unfolding and folding rate constants measured at different pH ranging from 2.0 to 7.2 at 25 °C. The lines are the best fit to a three-state model (Equation 1) with shared folding and unfolding m-values. Panel C and D: Chevron plots of the logarithm of unfolding and folding rate constants measured at different temperatures ranging from 15 to 42 °C and in 50 mM sodium-phosphate buffer at pH 7.2. Panel E and F: Chevron plots of the logarithm of the unfolding and folding rate constants measured in sodium-phosphate buffer at pH 7.2 with different ionic strengths ranging from 20 mM to 1 M and at 25 °C. The lines in panel C, D, E and F are the best fit to a two-state chevron.