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. 2017 Oct 3;7:12593. doi: 10.1038/s41598-017-12827-0

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Energy diagram for the folding of of PDZ3 (black) and PDZ3Δα3 (grey). Deletion of the of helix α3 affects slightly the stability of the native state without altering substantially the major folding pathway, which appears rather robust to the truncation.