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. 2017 Oct 3;7:12567. doi: 10.1038/s41598-017-12930-2

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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(A) Networks, weighed by correlation data, within KH-QUA2 domain of QKI protein is shown for mRNA-bound HOLO state and mRNA free APO state. Red colored nodes and edges correspond to interactions within 8 Å of mRNA. (B) Splitting of the networks into different communities are shown. (C) Change in CPL upon edge removal of nucleotide is shown for mRNA. Red and blue colored bars correspond to two nodes representing nucleotide base and sugar-phosphate backbone, respectively. (D) Change in CPL upon edge removal shown for KH-QUA2 domain for mRNA bound HOLO state (black colored) and mRNA free APO state (red colored). Structural elements are depicted as in Fig. 2B.