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. 2017 Oct 3;7:12639. doi: 10.1038/s41598-017-13027-6

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Analysis of differentially expressed proteins identified using LC-MS/MS between MO-EVs and NMO-EVs. (a) Volcano plot displaying Log₂ values for protein fold-change against Log₁₀ FDR. Proteins with a Log₂ fold difference below 1 and a statistical value of >0.05 (horizontal dashed line) were not considered to be statistically significant. Proteins found to be significantly upregulated in MO-EVs are displayed in red. Proteins that were significantly upregulated in NMO-EVs are displayed in green. Graphical representations of LC-MS/MS signal intensity plots for proteins found to be differentially expressed within (b) MO-EVs and (c) NMO-EVs. *^, **^, *** and **** signify P values of <0.05, <0.01, <0.001 and <0.0001, respectively. N = 3.

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