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Genetic modifications of talimogene laherparepvec. The viral gene ICP34.5 was deleted and replaced with a human granulocyte-macrophage colony-stimulating factor (hGM-CSF) expression cassette comprising the cytomegalovirus (CMV) promoter, hGM-CSF, and a bovine growth hormone polyadenylation (pA) signal. Expression of the viral gene US11 is driven by the ICP47 promoter
