Table 3.
Physiological data measured over a 70 min period in a horse during general anesthesia with xenon (70%) and oxygen (30%), co-administered with a lidocaine CRI at 0.05 mg kg−1 min−1.
| Time | T0 | T5 | T10 | T15 | T20 | T25 | T30 | T35 | T40 | T45 | T50 | T55 | T60 | T65 | T70 | T-24 | TR | TR + 2 | TR + 24 | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HR | (bpm) | 23 | 51 | 40 | 36 | 40 | 40 | 40 | 39 | 39 | 56 | 51 | 39 | 37 | 52 | 58 | – | – | – | – |
| SAP | (mmHg) | – | – | – | 100 | 95 | 95 | 91 | 100 | 88 | 110 | 94 | 89 | 100 | 83 | – | – | – | – | – |
| MAP | (mmHg) | – | – | – | 77 | 71 | 70 | 76 | 85 | 69 | 86 | 73 | 71 | 79 | 72 | – | – | – | – | – |
| DAP | (mmHg) | – | – | – | 61 | 55 | 54 | 51 | 60 | 48 | 67 | 67 | 56 | 64 | 63 | – | – | – | – | – |
| PE’CO2 | (mmHg) | 37 | 37 | 38 | 39 | 39 | 37 | 39 | 36 | 34 | 38 | 35 | 39 | 37 | 37 | 33 | – | – | – | – |
| (kPa) | 4.9 | 4.9 | 5.0 | 5.2 | 5.2 | 4.9 | 5.2 | 4.8 | 4.5 | 5.0 | 4.6 | 5.2 | 4.9 | 4.9 | 4.4 | – | – | – | – | |
| SpO2 | (%) | 91 | 87 | 80 | 87 | 85 | 86 | 81 | 85 | 85 | 84 | 86 | 83 | 80 | 81 | 82 | – | – | – | – |
| BIS | – | – | – | – | – | 84 | 62 | 61 | 81 | 61 | 41 | 65 | 74 | – | – | – | – | – | – | |
| FeXe | (%) | 0 | 61.5 | 67.9 | 67.9 | 67.7 | 65.3 | 68.6 | 64.9 | 69.3 | 64.6 | 64.8 | 65.6 | 66.1 | 62.9 | 59.7 | – | – | – | – |
| FiO2 | (%) | 98 | 86 | 24 | 28 | 24 | 28 | 26 | 27 | 23 | 29 | 29 | 29 | 29 | 31 | 35 | – | – | – | – |
| pH | – | – | 7.4 | – | – | – | 7.4 | – | – | – | – | – | 7.4 | – | – | – | – | – | – | |
| PaCO2 | (mmHg) | – | – | 47 | – | – | – | 47 | – | – | – | – | – | 51 | – | – | – | – | – | – |
| (kPa) | – | – | 6.3 | – | – | – | 6.3 | – | – | – | – | – | 6.8 | – | – | – | – | – | – | |
| PaO2 | (mmHg) | – | – | 47 | – | – | – | 45 | – | – | – | – | – | 45 | – | – | – | – | – | – |
| (kPa) | – | – | 6.3 | – | – | – | 6 | – | – | – | – | – | 6 | – | – | – | – | – | – | |
| SaO2 | (%) | – | – | 85 | – | – | – | 83 | – | – | – | – | – | 81 | – | – | – | – | – | – |
| HCO3− | (mmol L−1) | – | – | 28.8 | – | – | – | 29 | – | – | – | – | – | 30.1 | – | – | – | – | – | – |
| Hb | (g L−1) | – | – | 11 | – | – | – | 9.7 | – | – | – | – | – | 9.8 | – | – | – | – | – | – |
| TP | (g L−1) | – | – | 58 | – | – | – | – | – | – | – | – | – | 52 | – | – | – | – | – | – |
| Ht | (%) | – | – | 30 | – | – | – | – | – | – | – | – | – | 27 | – | – | – | – | – | – |
| Lactate | (mmol L−1) | – | – | 1.3 | – | – | – | – | – | – | – | – | – | 1.9 | – | – | – | – | – | – |
| Isoprostanes | (ng mL−1) | 61.2 | – | – | – | – | – | 23.9 | – | – | – | – | – | 29.4 | – | – | – | – | 3.8 | – |
| CK | (mmol L−1) | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | 243 | 301 | 364 | 202 |
| Ketamine | (mg kg−1) | – | – | – | – | – | 0.6 | – | 0.6 | – | 0.6 | – | – | 0.6 | – | 0.6 | – | – | – | – |
HR, heart rate; SAP, systolic arterial pressure; MAP, mean arterial pressure; DAP, diastolic arterial pressure; PE’CO2, expired pressure of carbon dioxide; SpO2, peripheral oxygen hemoglobin saturation; BIS, bispectral index; FeXe, expired fraction of xenon; FiO2, inspired fraction of oxygen. PaCO2, arterial partial pressure of carbon dioxide; PaO2, arterial blood oxygen tension; SaO2, arterial hemoglobin oxygen saturation; HCO3−, bicarbonate concentration; Hb, hemoglobin concentration; TP, total protein concentrations; Ht, hematocrit; Lactates, lactate plasma concentrations, CK, creatine kinase plasma concentrations.