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. 2017 Sep 29;8:1221. doi: 10.3389/fimmu.2017.01221

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Copyright © 2017 Bowers, Majchrzak, Nelson, Aksoy, Wyatt, Smith, Bailey, Neal, Hammerbacher and Paulos.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Human T cells primed with CAL-101 share transcriptional characteristics with stem memory lymphocytes. (A) Differential expression of memory and effector-associated genes in CAL-101 or AKTi-treated human T cells compared to vehicle analyzed using RNA sequencing (see also Figure S3 in Supplementary Material); n = 3 normal donors. (B) Western blot of nuclear protein extracts from vehicle, AKTi, or CAL-101-treated human T cells, B = β-catenin, L = Lef1, T = Tcf7, H = Histone H3; representative of 4–6 donors. (C) Quantified protein levels relative to Histone H3, RROD GOI/H = relative ratio of optical density (gene of interest over Histone H3); n = 4–6 normal donors. One-way repeated measures ANOVA; ns, not statistically significant, *p < 0.05.