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CAL-101 induces a strong memory phenotype and powerful antitumor capacity in chimeric antigen receptor (CAR) and TCR-reactive T cells. Graphical comparison of the memory capacity and antitumor efficacy of tumor-reactive T cells cultured in vehicle, AKT inhibitor (AKTi), or phosphatidylinositol-3-kinase p110δ (PI3Kδ) inhibitor (CAL-101).
