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GSH fine-tuning of TLR4 signaling. LPS triggers TLR4 to induce gene expression of inflammatory cytokines, antioxidant genes, and antiviral/immunity pathways. GSH orients the TLR4-mediated changes in gene expression profile toward activation of host defense. GSH, glutathione; LPS, lipopolysaccharide; TLR4, toll-like receptor 4.
