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. 2017 Sep 29;8:1239. doi: 10.3389/fimmu.2017.01239

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Copyright © 2017 Diotallevi, Checconi, Palamara, Celestino, Coppo, Holmgren, Abbas, Peyrot, Mengozzi and Ghezzi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of GSH depletion on LPS-induced changes in gene expression profile. The dataset was filtered to select transcripts that were affected by LPS (LPS vs control, first step), then by BSO (BSO + LPS vs LPS alone, second step). Cutoff for selection was 1.5-fold change and P < 0.05, using the Student’s t-test. Significantly different expressed genes were further selected by using one-way ANOVA, followed by a correction for multiple comparisons by controlling the false discovery rate with the two-stage step-up method of Benjamini, Krieger, and Yekutieli. The number of transcripts resulting from filtering is indicated and color coded (red, increased; green, decreased). ANOVA, analysis of variance; BSO, buthionine sulfoximine; GSH, glutathione; LPS, lipopolysaccharide.