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. 2017 Sep 29;8:1242. doi: 10.3389/fimmu.2017.01242

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Copyright © 2017 Schmidt, Herrero San Juan, Trautmann, Berninger, Schwiebs, Ottenlinger, Thomas, Zaucke, Pfeilschifter and Radeke.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Long-chain ceramides, showing a decrease in S1P5^−/− following BLM treatment. BLM-induced regulation of GluCer C18:0 (A), GluCer C24:1 (B), and ceramide C24:0 (C) in the skin of WT (black bars) and S1P5^−/− mice (gray bars). Lipid measurements were performed after extraction by LC-MS/MS analysis (ng/mg) and presented here for BLM-treated mouse groups as difference to the mean of respective PBS controls. Data are shown as mean ± SD of n = 4–5 mice/group with # indicating p ≤ 0.05, ** for p ≤ 0.01. Hashtags (#) characterize significance in comparison to the respective PBS controls. Statistical analysis was performed using a one-way ANOVA with Bonferroni’s multiple comparison test. (Δ = difference). ANOVA, analysis of variance; BLM, bleomycin; GluCer, glucosylceramide; LC-MS/MS, liquid chromatography coupled to tandem mass spectrometry; PBS, phosphate-buffered saline; WT, wild type.