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. 2017 Sep 29;8:1242. doi: 10.3389/fimmu.2017.01242

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Copyright © 2017 Schmidt, Herrero San Juan, Trautmann, Berninger, Schwiebs, Ottenlinger, Thomas, Zaucke, Pfeilschifter and Radeke.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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S1P5-dependent regulation of S1P1 and S1P3 mRNA in BLM-treated skin. Relative mRNA expression of (A) S1P1 and (B) S1P3 in skin tissue of BLM-treated WT (black bars) and S1P5^−/− (gray bars) mice. mRNA expression levels were determined by qRT-PCR analysis. All data are presented as fold change to the mean of the respective PBS controls and shown as mean ± SD of n = 3–5 mice/group with #/* indicating p ≤ 0.05, ## for p ≤ 0.01 and *** for p ≤ 0.001. Hashtags (#) characterize significance in comparison to the respective PBS controls (adjacent white bars). Statistical analysis was performed using a one sample t-test for # or an unpaired t-test for *. (rel. = relative). BLM, bleomycin; PBS, phosphate-buffered saline; qRT-PCR, quantitative real-time polymerase chain reaction; WT, wild type.