Figure 1.

Study design and cell yields of terminal ileum LPMC isolated from Ty21a-vaccinated and unvaccinated volunteers. (A) Oral typhoid vaccine Ty21a dosage schedule (4 doses at -21 to -14 days) and time of collection of specimens (blood and TI biopsies) from volunteers undergoing routine screening colonoscopies. Autologous EBV-B cells are generated from preimmunized blood. (B) Cell yield (number of viable cells/mg of tissue) was correlated to the age of volunteers (n = 35) using Pearson correlation test. (C) Cell yield comparison between Ty21a-vaccinated and unvaccinated volunteers. Median values for each group are denoted as horizontal black bars.