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. 2017 Sep 26;8:1851. doi: 10.3389/fmicb.2017.01851

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Copyright © 2017 Hidalgo-Cantabrana, Crawley, Sanchez and Barrangou.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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CRISPR subtype II-C spacers comparison in B. longum. The CRISPR spacers of CRISPR subtype II-C were represented using an Excel Macro tool. The spacers are represented by a square and each unique spacer sequence is indicated as a unique color and a geometric figure. Squares containing an “X” represent deleted or missing spacers (A). The last spacer acquired is represented on the left side while the first spacer is on the right side. The spacers schematic representation showed a common origin (right side) for the strains and the evolution trend in four different clusters numbered from i to iv (B).