Table 4.
PK/PD analysis of data acquired from ex vivo time–kill studies of tulathromycin against S. suis in porcine serum.
| Parameter (units)a | Values |
|---|---|
| E0 (log CFU/mL) | 1.76 |
| Emax (log CFU/mL) | -3.87 |
| Emax -E0 (log CFU/mL) | -5.63 |
| EC50 (h) | 17.9 |
| Slope (N) | 1.18 |
| AUC12h/MIC for static effect (h) | 9.62 |
| AUC12h/MIC for 1-log10 kill effect (h) | 18.9 |
| AUC12h/MIC for 2-log10 kill effect (h) | 32.7 |
aE0, difference in number of bacteria counts (log10 CFU/mL) in drug-free sample between 0 and 12 h; Emax, difference in greatest amount of bacterial reduction (log10 CFU/mL); EC50 is the AUC/MIC value producing 50% of the maximal antibacterial effect; N, the slope of AUC/MIC response curve.