Figure 6.

Mechanotyping of human breast cancer cell lines using q-DC. (A) Density scatter plots show E_a and β as functions of cell size for MCF-7 and MDA-231 cell lines. To compare cell populations, we bin data by cell size, as depicted by the dotted lines. Cell diameter is measured in the microfluidic channel before the cell enters the constriction. (B) Boxplots represent the size-binned distributions of E_a and β for cells with D_cell = 21 ± 1 μm. White lines represent the median. Boxes denote the interquartile ranges and whiskers denote the 10th–90th percentiles. White squares represent the bootstrapped medians. N > 100 for each cell type. The Mann-Whitney U test is used to determine statistical significance: ^∗∗p < 0.01, ^∗∗∗p < 0.001. To see this figure in color, go online.