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Domains and known interactions of SPEN protein. The scheme represents the 400 kDa (3643 amino acids) mouse SPEN protein and approximate position of computationally identified domains (NLS; nuclear localization signal). Known interactions of SPEN are indicated. The RNA binding domains and corepressor interacting domains have been implicated in Xist function, whereas the relevance of the other SPEN sequences to X inactivation remains to be investigated. (Online version in colour.)
