Table 1.
Direct and indirect genetic effects during family interactions. After the locus is identified, the phenotypes affected by the locus are listed with direct effects first, followed by the QTL position in Mb, the 1.5 LOD confidence interval, the genome-wide peak marker likelihood ratio statistic (LRS) and log of the odds (LOD) score and associated p-value, the number of genes within the interval, the allele that increases the trait value, and finally the coefficient of determination as obtained from a regression on BXD genotype. All loci have exceeded significance thresholds at the genome-wide level and corrected for multiple traits as outlined in the Material and methods except the indirect effect on B6 maternal activity at SocInt15, which narrowly missed the multiple trait threshold but was retained due to the high phenotypic correlation between the direct and indirect effect (electronic supplementary material, table S2).
| locus | phenotype | QTL position (Mb) | confidence interval (Mb) | max LRS | max LOD | max p | no. genes | allele increasing trait value | coefficient of determination (R2) |
|---|---|---|---|---|---|---|---|---|---|
| SocInt2 | BXD sibling solicitation d14 | 75.857–76.309 | 73.31–77.355 | 20.016 | 4.342 | 0.045 | 49 | D2 | 0.590 |
| B6 maternal suckling d14 | 74.928–75.515 | 74.928–75.515 | 6.426 | 1.394 | 0.992 | 49 | D2 | 0.601 | |
| SocInt4 | BXD sibling sucking d6 | 11.148–11.507 | 10.826–13.031 | 19.672 | 4.277 | 0.044 | 21 | B6 | 0.603 |
| B6 sibling activity d6 | 11.148–11.507 | 10.826–13.031 | 20.285 | 4.4 | 0.030 | 21 | B6 | 0.603 | |
| B6 sibling sucking d6 | 11.148–11.507 | 10.826–13.031 | 20.652 | 4.48 | 0.032 | 21 | B6 | 0.601 | |
| B6 maternal suckling d6 | 11.148–11.507 | 10.826–13.031 | 19.517 | 4.234 | 0.045 | 21 | B6 | 0.611 | |
| SocInt10 | BXD sibling sucking d14 | 101.578–102.633 | 99.07–103.025 | 23.537 | 5.117 | 0.035 | 17 | D2 | 0.597 |
| B6 sibling sucking d14 | 101.578–102.633 | 99.07–103.025 | 23.847 | 5.173 | 0.029 | 17 | D2 | 0.590 | |
| B6 maternal suckling d14 | 101.028 | 97.112–103.025 | 19.857 | 4.307 | 0.085 | 27 | D2 | 0.601 | |
| SocInt15 | BXD sibling sucking d14 | 3.619–4.349 | 3.229–6.298 | 14.671 | 3.189 | 0.223 | 19 | D2 | 0.597 |
| B6 maternal suckling d14 | 3.619–4.349 | 3.229–6.298 | 22.538 | 4.889 | 0.036 | 19 | D2 | 0.601 | |
| B6 sibling sucking d14 | 3.619–4.349 | 3.229–6.298 | 15.058 | 3.266 | 0.205 | 19 | D2 | 0.590 | |
| B6 maternal activity d14 | 3.619–4.349 | 3.229–7.273 | 12.373 | 2.684 | 0.551 | 26 | B6 | 0.670 |