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. 2017 Oct 4;7:12665. doi: 10.1038/s41598-017-13056-1

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Calibration of height, BMI, and diabetes polygenic risk scores. For each trait and method, the polygenic risk score values for the UKB validation set were divided into deciles. For each decile, the difference between the mean observed and predicted trait (95% confidence interval) is illustrated as a function of the mean predicted trait for that decile. The trait is expressed per SD unit for height (A) and BMI (B). A similar analysis was performed for diabetes, whereby the difference between the observed probability of diabetes and the predicted probability is illustrated as a function of the predicted probability for each decile.