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. 2017 Oct 4;7:12665. doi: 10.1038/s41598-017-13056-1

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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GraBLD polygenic risk score discrimination as a function of calibration set sample size. The size of the UKB calibration set varied from 20 to 10,000 for height and BMI, and from 3 to 1,000 case-control pairs for diabetes. For each calibration sample size, discrimination of the corresponding polygenic risk score was calculated in the independent UKB validation set (N = 130,215 for height and BMI; N = 5,746 case-control pairs for diabetes).