Table 2.

Univariate and multivariate Cox regression analysis of different prognostic variables for overall survival (OS) and recurrence free survival (RFS) prediction in ccRCC patients.

Characteristic	OS				RFS
	Univariate		Multivariate		Univariate		Multivariate
	HR (95% CI)	P a	HR (95% CI)	P a	HR (95% CI)	P a	HR (95% CI)	P a
Gender(Male vs Female)	1.037(0.556–1.934)	0.908	1.205(0.615–2.358)	0.587	1.228(0.733–2.059)	0.435	1.343(0.782–2.307)	0.284
Age,years (>55 vs ≤55)	1.250(0.682–2.290)	0.471	0.999(0.496–2.013)	0.998	1.417(0.850–2.361)	0.181	1.274(0.725–2.238)	0.400
Tumor size,cm (>4 vs ≤4)	7.791(3.447–17.607)	<0.001*	4.596(1.600–13.198)	0.005*	7.472(3.773–14.797)	<0.001*	5.666(2.517–12.755)	<0.001*
T classification (T3 + T4 vs T1 + T2)	11.583(5.912–22.693)	<0.001*	0.753(0.167–3.394)	0.711	5.185(3.067–8.766)	<0.001*	0.337(0.094–1.209)	0.095
N classification (N1 vs N0)	2.099(0.646–6.818)	0.217	1.075(0.289–4.006)	0.914	1.904(0.688–2.267)	0.215	1.328(0.438–4.028)	0.616
TNM stage (III + IV vs I + II)	10.006(5.261–19.028)	<0.001*	9.571(2.034–45.026)	0.004*	5.157(3.025–8.793)	<0.001*	9.613(2.456–37.623)	0.001*
Fuhrman grade (3 + 4 vs 1 + 2)	1.742(0.916–3.316)	0.091	3.779(1.645–8.680)	0.002*	2.628(1.568–4.405)	<0.001*	4.978(2.669–9.282)	<0.001*
Necrosis(Present vs Absent)	2.493(1.153–5.392)	0.020*	4.808(1.649–14.017)	0.004*	1.905(0.936–3.876)	0.076	3.734(1.548–9.004)	0.003*
FGL2 expression (High vs low)	6.636(2.579–17.080)	<0.001*	3.396(1.187–9.722)	0.023*	4.214(2.119–8.383)	<0.001*	2.940(1.402–6.166)	0.004*

HR = hazard ratio; CI = confidence interval. ^a P-value from the Cox proportional hazards model; *Statistically significant (P < 0.05).